Electroreductive cyclization reactions. Stereoselection, creation of quaternary centers in bicyclic frameworks, and a formal total synthesis of quadrone.
1990; Elsevier BV; Volume: 31; Issue: 4 Linguagem: Inglês
10.1016/0040-4039(90)87014-q
ISSN1873-3581
AutoresC. Gregory Sowell, Ronald Wolin, R. Daniel Little,
Tópico(s)Axial and Atropisomeric Chirality Synthesis
ResumoThe electroreductive cyclization reaction has been successfully applied to an efficient formal total synthesis of quadrone (1). Two of the four rings were created electrochemically, a third via a novel oxidativedecarboxylation and cyclization onto a remote nitrile functional group (22å24).
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