Transient hypogammaglobulinemia, elevated immunoglobulin E levels, and food allergy
1979; Elsevier BV; Volume: 64; Issue: 3 Linguagem: Inglês
10.1016/0091-6749(79)90098-8
ISSN1097-6825
AutoresStanley M. Fìneman, Fred S. Rosen, Raif S. Geha,
Tópico(s)Congenital Ear and Nasal Anomalies
ResumoFour infants presented with the combination of food allergy, transient hypogammaglobulinemia (THI), and elevated serum IgE levels.Food allergy was documented by history, positive skin tests for immediate hypersensitivity, radioallergosorbent test, histamine release studies, and lymphocyte transformation in response to food allergens.THI was probably secondary to decreased production since there was no evidence of protein loss from the gastrointestinal tract.Immunologic studies revealed normal B cell number and function in vitro.T cell number and proliferative response to mitogens and antigen were normal but T cells were dejcient in their ability to generate helper factors necessary for B cell maturation into immunoglobulin secretoq cells.The THI and the dejicient production of T cell -helper factor resolved after the age qf 20 to 24 mo.A defect in immunoregulation may be responsible for the immunologic abnormalities observed in these patients and their propensity to develop IgE antibodies to food allergens.Transient hypogammaglobulinemia (THI) of infancy results from a delay in the maturation of immunoglobulin producti0n.lAffected infants have a propensity to recurrent infections until the age of 18 to 36 mo when normal levels of immunoglobulins are attained.THI has been poorly documented in the literature"' and a recent report suggests that it is a rather uncommon condition.5Documented food allergy is also a relatively uncommon disease affecting less than 0.5% of infants.6,' It is often transient, abating spontaneously by the end of the second year of life.83gThe present report examines four infants with THI, food allergy, and elevated serum IgE levels.Immu
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