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Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models

2011; Elsevier BV; Volume: 515; Issue: 1-2 Linguagem: Inglês

10.1016/j.abb.2011.08.011

1096-0384

Amy A. Irving, Richard B. Halberg, Dawn M. Albrecht, Lori A. Plum, Kathleen J. Krentz, Linda Clipson, Norman R. Drinkwater, James Amos‐Landgraf, William F. Dove, Hector F. DeLuca,

Microscopic Colitis

Epidemiological studies indicate that sunlight exposure and vitamin D are each associated with a lower risk of colon cancer. The few controlled supplementation trials testing vitamin D in humans reported to date show conflicting results. We have used two genetic models of familial colon cancer, the ApcPirc/+ (Pirc) rat and the ApcMin/+ (Min) mouse, to investigate the effect of 25-hydroxyvitamin D3 [25(OH)D3] and two analogs of vitamin D hormone on colonic tumors. Longitudinal endoscopic monitoring allowed us to test the efficacy of these compounds in preventing newly arising colonic tumors and in affecting established colonic tumors. 25(OH)D3 and two analogs of vitamin D hormone each failed to reduce tumor multiplicities or alter the growth patterns of colonic tumors in the Pirc rat or the Min mouse.