Portal de Periódicos da CAPES

Endolymphatic hydrops and blood–labyrinth barrier in Ménière's disease

2011; Taylor & Francis; Volume: 131; Issue: 5 Linguagem: Inglês

10.3109/00016489.2010.534114

1651-2251

Mitsuhiko Tagaya, Masahiro Yamazaki, Masaaki Teranishi, Shinji Naganawa, Tadao Yoshida, Hironao Otake, Seiichi Nakata, Michihiko Sone, Tsutomu Nakashima,

Cerebral Venous Sinus Thrombosis

Conclusions: The blood–labyrinth barrier is impaired in association with the hydrops grade in Ménière's disease. Objectives: To investigate the relationship between endolymphatic hydrops and the clinical characteristics of patients with Ménière's disease revealed by 3 T magnetic resonance imaging (MRI). Methods: A double dose of gadoteridol (Gd; 0.2 mmol/kg) was injected intravenously in 12 patients with Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery MRI and three-dimensional real inversion recovery MRI 4 h later using a 3 T MRI unit. Ten patients had unilateral and two had bilateral Ménière's disease. Results: Fourteen ears with Ménière's disease showed intense Gd contrast on MRI compared with that in the 10 asymptomatic contralateral ears of patients with unilateral Ménière's disease (1.12 ± 0.36 vs 0.82 ± 0.15). The hydrops grade was correlated significantly with the contrast effect. The 14 ears with Ménière's disease had endolymphatic hydrops. Of the 10 contralateral ears of patients with unilateral Ménière's disease, 2 had endolymphatic hydrops in the cochlea and 6 had endolymphatic hydrops in the vestibule.