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BIBTEX RIS

Allosteric regulation of phenylalanine hydroxylase

2011; Elsevier BV; Volume: 519; Issue: 2 Linguagem: Inglês

10.1016/j.abb.2011.09.012

ISSN

1096-0384

Autores

Paul F. Fitzpatrick,

Tópico(s)

Pharmacogenetics and Drug Metabolism

Resumo

The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.

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