The SRC Family Protein Tyrosine Kinase p62 yes Controls Polymeric IgA Transcytosis In Vivo
1999; Elsevier BV; Volume: 4; Issue: 4 Linguagem: Inglês
10.1016/s1097-2765(00)80213-0
ISSN1097-4164
AutoresFrédéric Luton, Marcel Vergés, Jean-Pierre Vaerman, Marius Sudol, Keith E. Mostov,
Tópico(s)Erythrocyte Function and Pathophysiology
ResumoTranscytosis of polymeric immunoglobulin A (pIgA) across epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR). Binding of pIgA to pIgR stimulates transcytosis of the pIgA–pIgR complex via a signal transduction pathway that is dependent on a protein tyrosine kinase (PTK) of the SRC family. Here we identify the PTK as p62 yes. We demonstrate the specific physical and functional association of the pIgR with p62 yes in rodent liver. Analysis of p62 yes knockout mice revealed a dramatic reduction in the association of tyrosine kinase activity with the pIgR and in transcytosis of pIgA. We conclude that p62 yes controls pIgA transcytosis in vivo.
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