Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
2010; Elsevier BV; Volume: 24; Issue: 2 Linguagem: Inglês
10.1038/modpathol.2010.200
ISSN1530-0285
AutoresSunil Badve, David J. Dabbs, Stuart J. Schnitt, Frederick L. Baehner, Thomas Decker, Vincenzo Eusebi, Stephen B. Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R. Lakhani, José Palacios, Emad A. Rakha, Andrea L. Richardson, Fernando Schmitt, Puay‐Hoon Tan, Gary M. Tse, Britta Weigelt, Ian O. Ellis, Jorge S. Reis‐Filho,
Tópico(s)Cancer and Skin Lesions
ResumoBreast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for ‘basal-like cancer’, which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists.
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