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Blind Alleys in Diabetes Research

1986; Wiley; Volume: 3; Issue: 5 Linguagem: Alemão

10.1111/j.1464-5491.1986.tb00783.x

1464-5491

Timothy Dornan, R. B. Tattersall,

Diabetes Management and Research

Diabetic MedicineVolume 3, Issue 5 p. 413-418 Blind Alleys in Diabetes Research Muscle Capillary Basement Membrane Thickening: Marker of Microvascular Complications or False Prophet? T. L. Dornan, T. L. Dornan Department of Medicine, University Hospital, Nottingham NG7 2UHSearch for more papers by this authorR. B. Tattersall, R. B. Tattersall Department of Medicine, University Hospital, Nottingham NG7 2UHSearch for more papers by this author T. L. Dornan, T. L. Dornan Department of Medicine, University Hospital, Nottingham NG7 2UHSearch for more papers by this authorR. B. Tattersall, R. B. Tattersall Department of Medicine, University Hospital, Nottingham NG7 2UHSearch for more papers by this author First published: September/October 1986 https://doi.org/10.1111/j.1464-5491.1986.tb00783.xCitations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Alberti KGMM. Editorial Comment. Diabetologia 1978; 15: 359– 360 2 Gundersen HJ, Osterby R., Lundbaek K.. The basement membrane controversy. Diabetologia 1978; 15: 361– 363 3 Siperstein MD, Feingold KR, Bennet PH. Hyperglycaemia and diabetic microangiopathy. Diabetologia 1978; 15: 365– 367 4 Williamson JR, Kilo C.. A common sense approach resolves the basement membrane controversy and the NIH Pima Indian Study. Diabetologia 1979; 17: 129– 131 5 Peterson CM, Jones RL, Esterly JA, Wantz GE, Jackson RL. Changes in basement membrane thickening and pulse volume concomitant with improved glucose control and exercise in patients with insulin-dependent diabetes mellitus. Diabetes Care 1980; 3: 586– 589 6 Camerini-Davalos RA, Velasco C., Glasser M., Bloodworth JMB Jr. Drug-induced reversal of early diabetic microangiopathy. N Engl J Med 1983; 309: 1551– 1556 7 Raskin P., Pietri AO, Unger R., Shannon WA Jr. The effect of diabetic control on the width of skeletal-muscle capillary basement membrane in patients with type 1 diabetes mellitus. N Engl J Med 1983; 309: 1546– 1550 8 Ashton N.. Vascular changes in diabetes with particular reference to the retinal vessels. Br J Opthalmol 1949; 33: 407– 420 9 Friedenwald JS. Diabetic retinopathy. Am J Opthalmol 1950; 33: 1187– 1199 10 Aagenaes O., Moe H.. 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New York: Raven Press, 1979; 167– 188. 17 Camerini-Davalos RA, Oppermann W., Rebigliati H., Glasser M., Bloodworth JMB. Muscle capillary basement membrane width in genetic prediabetes. J Clin Endocrinol Metab 1979; 48: 251– 259 14 Williamson JR, Vogler NJ, Kilo C.. Basement membrane thickening in muscle capillaries. Observations on diabetics and nondiabetics with both parents diabetic. Proceedings of the Fourth International Congress of Endocrinology. Amsterdam: Excerpta Medica, 1972; 1122– 1128. 19 Danowski TS, Fisher ER, Park EJ, Khurana RC, Nolan S., Stephan T.. Capillary basement membranes in muscle in glucose intolerance of the chemical diabetes type. Am J Clin Pathol 1974; 61: 718– 723 14 Fajans S., Williamson JR, Weissman PN, Vogler NJ, Kilo C., Conn JW. Basement membrane thickening in latent diabetes. Adv Metab Disord 1973; suppl 2: 393– 399. 21 Kilo C., Vogler N., Williamson JR. Muscle capillary basement membrane changes related to aging and to diabetes mellitus. Diabetes 1972; 21: 881– 905 14 Yodaiken RE. The capillaries of South African Diabetics in perspective. Adv Metab Disord 1973; suppl 2: 341– 347. 23 Peterson GE, Forsham PH. Variation in thickness of the capillary basement membrane in single muscles of diabetic subjects. Diabetes 1979; 28: 548– 551 24 Siess EA, Nathke HE, Dexel T., Haslbeck M., Mehnert H., Wieland OH. Dependency of muscle capillary basement membrane thickness on the duration of diabetes. Diabetes Care 1979; 2: 472– 478 25 Deckert T., Egeberg J., Moller Frimodt C., Sander E., Svejgaard A.. Basement membrane thickness, insulin antibodies and HLA antigens in longstanding insulin-dependent diabetics with and without severe retinopathy. Diabetologia 1979; 17: 91– 96 14 Ireland JT, Viberti GC, Watkins PJ. The Kidney and Renal Tract. In: Complications of Diabetes. H. Keen, RJ Jarrett (Eds). London: Edward Arnold, 1982; 137– 178. 27 Pardo V., Perez-Stable E., Alzamora DB, Cleveland WW. Incidence and significance of muscle capillary basal lamina thickness in juvenile diabetes. Am J Pathol 1972; 68: 67– 80 28 Williamson JR, Vogler NJ, Kilo C.. Regional variations in the width of the basement membrane of muscle capillaries in man and giraffe. Am J Pathol 1971; 63: 359– 368 29 Vracko R., Benditt EP. Manifestations of diabetes mellitus their possible relationship to an underlying cell defect. Am J Pathol 1974; 75: 204– 221 30 Sosenko JM, Miettinen OS, Williamson JR, Gabbay KH. Muscle capillary basement-membrane thickness and long-term glycaemia in type 1 diabetes mellitus. N Engl J Med 1984; 311: 694– 698 31 Aronoff SL, Bennett PH, Williamson JR, Siperstein MD, Plumer ME, Miller M.. Muscle capillary basement membrane (MCBM) measurements in prediabetic, diabetic and normal Pima Indians and Caucasians. Clin Res 1976; 24: 455 (abstract). 32 Karam JH, Rosenthal M., O'Donnel JJ et al Discordance of diabetic microangiopathy in identical twins. Diabetes 1976; 25: 24– 28 33 Ganda OP, Soeldner JS, Gleason RE, Smith TM, Kilo C., Williamson JR. Monozygotic triplets with discordance for diabetes mellitus and diabetic microangiopathy. Diabetes 1977; 26: 469– 479 34 Ganda OP, Williamson JR, Soeldner JS et al Muscle capillary basement membrane width and its relationship to diabetes mellitus in monozygotic twins. Diabetes 1983; 32: 549– 556 35 Barnett AH, Spiliopoulos AJ, Pyke DA et al. Muscle capillary basement membrane in identical twins discordant for insulin-dependent diabetes. Diabetes 1983; 32: 557– 560 36 Steffes MW, Sutherland DER, Goetz FC, Rich SS, Mauer SM. Studies of kidney and muscle biopsy specimens from identical twins discordant for type 1 diabetes mellitus. N Engl J Med 1985; 312: 1282– 1287 37 Marks JF, Raskin P., Stastny P.. Increase in capillary basement membrane width in parents of children with type 1 diabetes mellitus. Association with HLA-DR4. Diabetes 1981; 30: 475– 480 38 Raghu P., Asplin C., Dornan TL et al. Increased beta-cell secretory activity associated with HLA-DR4. 11th Congress of the International Diabetes Federation. Amsterdam: Excerpta Medica (International Congress Series no. 577), 1982; p 5 (abstract). 39 Dornan TL, Ting A., McPherson CK et al. Genetic susceptibility to the development of retinopathy in insulin-dependent diabetes. Diabetes 1982; 31: 226– 231 40 Dornan TL, Pecoraro R., Hansen J., Vracko R.. Capillary basement membrane thickening, insulin responses and HLA: a study of parents of insulin-dependent diabetic patients (IDD). Diabetes 1984; 33 (suppl 1): 40A (abstract). 41 Mauer M., Steffes M., Johnson E. et al. Skeletal muscle basement membrane in maturity-onset diabetes in the young. Diabetes 1985; 34: 321– 325 42 Raskin P., Marks JF, Berns H., Plumer MF, Siperstein MD. Capillary basement membrane width in diabetic children. Am J Med 1975; 58: 365– 372 43 Danowski TS, Fisher ER, Khurana RC, Nolan S.. Stephan T.. Muscle capillary basement membrane in juvenile diabetes mellitus. Metabolism 1972; 21: 1125– 1132 44 Soler NG, Fitzgerald MG, Malins JM. Retinopathy at diagnosis of diabetes with special reference to patients under 40 years of age. Br Med J 1969; 3: 567– 569 45 Pometta DM, Amherdt M., Rufener C., Scherrer JR. Capillary basement membrane thickness in early diabetes. Adv Metab Disord 1973; suppl 2: 357– 361. 46 Kilo C., Miller JP, Williamson JR. Capillary basement membrane (CBM) thickening (CBMT) and risk factors for vascular disease in University Group Diabetes Program subjects Diabetes 1982; 31 (suppl 2): 26A (abstract). 47 Rogers DG, Miller JP, Kilo C., Williamson JR. Maturation and glycaemic control are independently associated with microvascular disease in diabetic children. Diabetes 1984; 33 (suppl 1): 53A (abstract). 48 Mauer SM, Sutherland DER, Steffes MW et al. Pancreatic islet transplantation: effects on the glomerular lesions of experimental diabetes in the rat. Diabetes 1974; 23: 748– 753 49 Mauer SM, Steffes MW, Sutherland DER, Najarian JS, Michael AF, Brown DM. Studies of the rate of regression of the glomerular lesions in diabetic rats treated with pancreatic transplantation. Diabetes 1975; 24: 280– 285 50 Yodaiken RE, Menefee M., Seftel HC, Kew MC, McClaren MJ. Capillaries of South African diabetics. IV. Relation to retinopathy. Diabetes 1975; 24: 286– 290 51 Lander T., Dexel T., Naethke HE, Siess EA. Basement membrane thickness (BMT) in subgroups of type 1 diabetes mellitus with respect of retinopathy (DR), smoking and HLA-antigens. Diabetologia 1980; 19: 293(abstract). 52 Dunn PJ, Donald RA, Day T., Stewart JM, Stewart AW. The association between diabetic retinopathy and skeletal muscle capillary lamina thickening corrected for the influence of age and duration of diabetes. Diabetes 1979; 28: 858– 864 53 Williamson JR, Kilo C.. The relationship between glomerular and skeletal muscle capillary basement membrane. Diabetes 1978; 27: 513 (abstract). 54 Mauer SM, Steffes MW, Ellis EN, Sutherland DER. Brown DM, Goetz FC. Structural-functional relationships in diabetic nephropathy. J Clin Invest 1984; 74: 1143– 1155 Citing Literature Volume3, Issue5September/October 1986Pages 413-418 ReferencesRelatedInformation