A comparison of the effects of quinolinate and N-methyl-aspartate on neurons in rat piriform cortex
1986; Elsevier BV; Volume: 63; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(86)90014-5
ISSN1872-7972
AutoresJ. M. H. ffrench-Mullen, Nobuaki Hori, David O. Carpenter,
Tópico(s)Ion channel regulation and function
ResumoQuinolinate has been proposed to be the endogenous ligand of the N-methyl-aspartate (NMA) receptor in the mammalian central nervous system. We have compared the relative potency and pharmacologic sensitivity of quinolinate- and NMA-induced excitation on pyramidal cells in the rat piriform cortex. Quinolinate was considerably less potent than NMA, but the NMA responses were more sensitive to antagonism by NMA-receptor antagonists. These results suggest that, at least in this preparation, quinolinate and NMA are pharmacologically distinguishable and may act at different receptor sites.
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