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Quinolizidine alkaloids from Lupinus lanatus

2011; Elsevier BV; Volume: 1004; Issue: 1-3 Linguagem: Inglês

10.1016/j.molstruc.2011.07.061

1872-8014

Alexandre T. Neto, Carolina Quatrin Oliveira, Vinícius Ilha, Marcelo Pedroso, Robert A. Burrow, Ionara I. Dalcol, Ademir F. Morel,

Chromatography in Natural Products

Abstract In this study, one new quinolizidine alkaloid, lanatine A (1), together with three other known alkaloids, 13-α-trans-cinnamoyloxylupanine (2), 13-α-hydroxylupanine (3), and (−)-multiflorine (4) were isolated from the aerial parts of Lupinus lanatus (Fabaceae). The structures of alkaloids 1–4 were elucidated by spectroscopic data analysis. The stereochemistry of 1 was determined by single crystal X-ray analysis. Bayesian statistical analysis of the Bijvoet differences suggests the absolute stereochemistry of 1. In addition, the antimicrobial potential of alkaloids 1–4 is also reported.