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Antimalarial compounds from Hoslundia opposita

1992; Elsevier BV; Volume: 31; Issue: 11 Linguagem: Inglês

10.1016/s0031-9422(00)97526-5

1873-3700

Hans Achenbach, Reiner Waibel, Mayunga H.H. Nkunya, Hugo Weenen,

Mosquito-borne diseases and control

Four new abietane-type esters, 3-O-benzoylhosloppone, 3-O-cinnamoylhosloppone, 3-O-benzoylhinokiol and 3-O-benzoylhosloquinone were isolated from the root bark of the antimalarial plant Hoslundia opposita Vahl. and their structures were determined by a combination of spectroscopic methods and chemical correlations. 3-O-Benzoylhosloppone inhibits the growth of the multidrug resistant strain K1 of Plasmodium falciparum in vitro with an IC50-value of 0.4 μg ml−1.