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Magnetocardiographic analysis of the two-dimensional distribution of intra-QRS fractionated activation

1999; IOP Publishing; Volume: 44; Issue: 1 Linguagem: Inglês

10.1088/0031-9155/44/1/009

1361-6560

H-P Müller, P. Gödde, K. Czerski, M. Oeff, R. Agrawal, P. Endt, Wolfgang Kruse, Uwe Steinhoff, Lutz Trahms,

Cardiac electrophysiology and arrhythmias

The spatial distribution of high-frequency components in magnetic signals during the QRS complex of the human heartbeat was investigated. Cardiomagnetic signals were recorded simultaneously using 49 first-order magnetogradiometer channels of a multi-SQUID system with a low noise power density. The QRS fragmentation score S, as a measure of the fragmentation of the bandpass-filtered QRS complex, was examined for its sensitivity and specificity to discriminate 34 healthy volunteers, 42 post-myocardial infarction patients and 43 patients with coronary heart disease and with a history of malignant sustained ventricular tachycardia or ventricular fibrillation. The multichannel information was visualized by two-dimensional mapping of the score values of the single channels. By averaging the score values for the seven central channels, , the score values of all 49 channels, , and calculating the standard deviation for all 49 channels, , a higher sensitivity and specificity for detecting patients with ventricular tachycardia (VT) or ventricular fibrillation (VF) was reached than by analysis of a single channel. Combination of these parameters furnishes a sensitivity of 90% and a specificity of 70% for identifying patients prone to VT/VF.