Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina
2003; Elsevier BV; Volume: 62; Issue: 3 Linguagem: Inglês
10.1016/s0166-445x(02)00091-7
ISSN1879-1514
AutoresKenneth A. Beattie, Judith Ressler, Claudia Wiegand, Eberhard Krause, Geoffrey A. Codd, Christian E. W. Steinberg, Stephan Pflugmacher,
Tópico(s)Marine Toxins and Detection Methods
ResumoThe toxicity and metabolism of the cyanobacterial toxins microcystin-LR (MCLR), Dhb-microcystin-HtyR and nodularin were investigated in the cysts, nauplii and adults of the brine shrimp Artemia salina. The presence of the phase II detoxication system glutathione S-transferase (sGST) in these stages was shown using different substrates. Exposure of adult A. salina to the toxins led to an elevation of GST activity in vivo. All three toxins were conjugated to glutathione via GST, which has been shown as an initial step of microcystin and nodularin detoxication.
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