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Development and Validation of the Korean Version of Expanded Prostate Cancer Index Composite: Questionnaire Assessing Health-Related Quality of Life after Prostate Cancer Treatment

2010; The Korean Urological Association; Volume: 51; Issue: 9 Linguagem: Inglês

10.4111/kju.2010.51.9.601

2005-6745

Kyung Jin Chung, Jung Jun Kim, Soo Hyun Lim, Tae Heon Kim, Deok Hyun Han, Sung Won Lee,

Bladder and Urothelial Cancer Treatments

Purpose: Although the quality of life (QoL) of prostate cancer (PCa) patients is a major issue, there is no unified and useful methodology for assessing QoL.The Expanded Prostate Cancer Index Composite (EPIC) is a globally used tool to measure QoL after PCa treatment that comprises urinary, bowel, sexual, and hormonal domains.Acknowledging the need for such a tool applicable to Korean PCa patients, we translated EPIC into Korean and validated the new version. Materials and Methods:The Korean version of EPIC was devised by translation, back-translation, and reconciliation.Subsequently, we randomly selected 153 patients with localized PCa treated with radical perineal prostatectomy (67, 43.8%), radical retropubic prostatectomy (19, 12.4%), laparoscopic radical prostatectomy (12, 7.8%), robot-assisted laparoscopic radical prostatectomy (36, 23.5%), and high-intensity focused ultrasound ablation of the prostate (19, 12.4%) and asked them to complete EPIC.Reliability was assessed by test-retest correlation and Cronbach's alpha.Validity was assessed by factor analysis, interscale correlation, and correlation with Functional Assessment of Cancer Therapy-Prostate (FACT-P).Results: Test-retest correlation and Cronbach's alpha were high in each of the domains (0.92, 0.91, 0.76, 0.84 and 0.86, 0.84, 0.92, 0.83, p＜0.0001).Interscale correlation among the domains was low (r＜0.37),which indicated that EPIC is composed of proper domains.Interscale correlation between the function and bother subscales was high (0.94, 0.81, 0.84 and 0.80, p＜0.0001).EPIC domains had low correlation with FACT-P, permitting complementary use. Conclusions:The Korean version of EPIC was developed by a proper process, as evident by its high reliability and validity.Therefore, it is a reliable, comprehensive, systematic method that evaluates QoL in Korean patients after PCa treatment.Furthermore, it can be adapted as an objective methodology for research globally.