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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

2009; American Association for the Advancement of Science; Volume: 325; Issue: 5938 Linguagem: Inglês

10.1126/science.1173155

1095-9203

Samir K. Maji, Marilyn H. Perrin, M.R. Sawaya, Sebastian Jessberger, Krishna C. Vadodaria, Robert A. Rissman, Praful S. Singru, K. Peter R. Nilsson, Rozalyn Simon, David Schubert, David Eisenberg, Jean Rivier, Paul E. Sawchenko, Wylie Vale, Roland Riek,

Endoplasmic Reticulum Stress and Disease

Plethora of Secretory Amyloids Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson's disease, and type II diabetes. In addition, a few functional amyloid systems are known: the prions of fungi, the bacterial protein curli, the protein of chorion of the eggshell of silkworm, and the amyloid protein Pmel-17 involved in mammalian skin pigmentation. Now Maji et al. (p. 328 , published online 18 June) propose that endocrine hormone peptides and proteins are stored in an amyloid-like state in secretory granules. Thus, the amyloid fold may represent a fundamental, ancient, and evolutionarily conserved protein structural motif that is capable of performing a wide variety of functions contributing to normal cell and tissue physiology.