Displacement of tolbutamide, glibenclamide and chlorpropamide from serum albumin by anionic drugs
1976; Elsevier BV; Volume: 25; Issue: 10 Linguagem: Inglês
10.1016/0006-2952(76)90365-8
ISSN1873-2968
AutoresKenneth F. Brown, Michael J. Crooks,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoThe binding of tolbutamide, chlorproramide and glibenclamide to human and bovine serum albumin has been estimated in the presence of a number of acidic drugs. It is shown that agreement between experimental data and that calculated using the competitive binding equation is very poor. The degree of displacement of tolbutamide and chlorpropamide is much greater than that calculated using the equation while displacement of glibenclamide is much less. These findings suggest that displacement is essentially non-competitive and that glibenclamide is less susceptible to displacement by acidic drugs than tolbutamide or chlorpropamide.
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