Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion
1984; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês
10.1016/0167-0115(84)90066-1
ISSN1873-1686
AutoresJens J. Holst, Jan Fahrenkrug, Svend Knuhtsen, S L Jensen, Steen Seier Poulsen, O. Vagn Nielsen,
Tópico(s)Gastroesophageal reflux and treatments
ResumoVasoactive intestinal polypeptide (VIP) in the pig pancreas is localized to nerves, many of which travel along the pancreatic ducts. VIP stimulates pancreatic fluid and bicarbonate secretion like secretin. Electrical vagal stimulation in the pig causes an atropine-resistant profuse secretion of bicarbonate-rich pancreatic juice. In an isolated perfused preparation of the pig pancreas with intact vagal nerve supply, electrical vagal stimulation caused an atropine-resistant release of VIP, which accurately parallelled the exocrine secretion of juice and bicarbonate. Perfusion of the pancreas with a potent VIP-antiserum inhibited the effect of vagal stimulation on the exocrine secretion. It is concluded, that VIP is responsible for (at least part of) the neurally controlled fluid and bicarbonate secretion from the pig pancreas.
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