A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials
2009; American Chemical Society; Volume: 3; Issue: 7 Linguagem: Inglês
10.1021/nn9005973
ISSN1936-086X
AutoresHuan Meng, Tian Xia, Saji George, André E. Nel,
Tópico(s)Heavy Metal Exposure and Toxicity
ResumoThe rate of expansion of nanomaterials calls for the consideration of appropriate toxicological paradigms in the safety assessment of nanomaterials. We advocate a predictive toxicological paradigm for the assessment of nanomaterial hazards. The predictive toxicological approach is defined as establishing and using mechanisms and pathways of injury at a cellular and molecular level to prioritize screening for adverse biological effects and health outcomes in vivo. Specifically as it relates to nanomaterials, a predictive approach has to consider the physicochemical properties of the material that leads to molecular or cellular injury and also has to be valid in terms of disease pathogenesis in whole organisms.
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