Release of acetylcholine from isolated human cortical slices: Inhibitory effect of norepinephrine and phenytoin
1981; Elsevier BV; Volume: 73; Issue: 1 Linguagem: Inglês
10.1016/0014-4886(81)90051-0
ISSN1090-2430
AutoresE. Sylvester Vizi, E. Pásztor,
Tópico(s)Epilepsy research and treatment
ResumoThe release of acetylcholine from human isolated brain cortical slices was studied. Both K excess (47.3 mm) and inhibition of Na+K+-activated ATPase by ouabain (2 × 10−5m) significantly enhanced the release of acetylcholine. l-Norepinephrine (10−6m) and phenytoin (10−6m) reduced the release of acetylcholine evoked by ouabain. When the temperature was decreased to 15°C, ouabain failed to increase the release of acetylcholine, although the resting release was not affected.
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