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The effects of dopamine agonists and antagonists on Na+, K+-ATPase and Mg2+-atpase activities of synaptosomes

1982; Elsevier BV; Volume: 31; Issue: 8 Linguagem: Inglês

10.1016/0006-2952(82)90377-x

1873-2968

Abdul Halim Sawas, John Gilbert,

Cholinesterase and Neurodegenerative Diseases

The effects of dopamine agonists and antagonists on the Na+,K+-ATPase and Mg2+-ATPase activities of rat cerebral cortex synaptosomes have been determined. Dopamine, ADTN, apomorphine and S-584, but not piribedil, stimulated the activities of the enzymes. The stimulatory effect of dopamine was not antagonised by dopamine antagonists and apparently the catechol group is responsible for the enzyme stimulation.