Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization
1993; Wiley; Volume: 7; Issue: 4 Linguagem: Inglês
10.1002/gcc.2870070404
ISSN1098-2264
AutoresHirofumi Kobayashi, Rafael Espinosa, Michael J. Thirman, Anthony A. Fernald, Kevin Shannon, Manuel O. Dı́az, Michelle M. Le Beau, Janet D. Rowley,
Tópico(s)Genomic variations and chromosomal abnormalities
ResumoAbstract Fluorescence in situ hybridization (FISH) was performed on bone marrow or peripheral blood cells thought to contain a del(11)(q23q25) from four patients who had acute leukemia or myelodysplasia. Cells from all patients were shown to contain translocations that involved chromosome 6 in three of them. Our data suggest that a large proportion of presumptive del(11)(q23) or del(11)(q23q25) chromosomes may represent previously unidentified translocations that can be detected by FISH. © 1993 Wiley‐Liss, Inc.
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