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Focal segmental glomerulosclerosis – epidemiology aspects in children and adults

2006; Springer Science+Business Media; Volume: 22; Issue: 2 Linguagem: Inglês

10.1007/s00467-006-0370-5

1432-198X

Ronald J. Hogg, John P. Middleton, V. Matti Vehaskari,

Biomedical Research and Pathophysiology

The histologic features of idiopathic forms of focal segmental glomerulosclerosis (FSGS) were first described by Theodor Fahr in the Handbuch der speziellen pathologischen Anatomie und Histologie in 1925 [1]. Over the subsequent eight decades much has been written about the histologic features and clinical characteristics of patients with FSGS, but it is only in recent years that attention has been directed to the incidence and prevalence of the disorder in various populations. This article will provide an overview of the epidemiology of FSGS by reviewing published surveys of renal biopsies, experiences from clinical registries of children with renal insufficiency, and data from the U.S. Renal Data Systems (USRDS).