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Female Sex Steroid Hormones Modify Some Regulatory Properties of Monocyte‐Derived Dendritic Cells

2007; Wiley; Volume: 58; Issue: 5 Linguagem: Inglês

10.1111/j.1600-0897.2007.00526.x

1600-0897

Dobroslav Kyurkchiev, Ekaterina Ivanova‐Todorova, Soren Hayrabedyan, Iskra Altankova, Stanimir Kyurkchiev,

Immunotherapy and Immune Responses

Problem Monocyte‐derived dendritic cells (mDCs) are present in human decidua during the first month of pregnancy where they experience the effect of the increased concentration of progesterone (Pg) and estradiol (Estr). The aim of our study was to assess the effect of these reproductive hormones on the immunomodulatory role of mDCs. Methods of study The mDCs cultured in vitro in the presence of sex steroid hormones and characterized for their apoptosis and secretion of cytokines by flow cytometry, enzyme linked immunosorbent assay and proteome profiler kit. Results Female sex steroid hormones enhance the life cycle of mDCs, thus increasing the maturation and apoptosis, they also increase the production of interleukin (IL)‐10 and IL‐27 but only Pg increases the production of IL‐13 and down regulates the secretion of IL‐23. Conclusion The Pg and Estr participate in the regulation of the immune response during pregnancy by influencing apoptosis and the cytokine profile of the mDCs.