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"Big" Growth Hormone Components from Human Plasma: Decreased Reactivity Demonstrated by Radioreceptor Assay

1973; American Association for the Advancement of Science; Volume: 182; Issue: 4114 Linguagem: Inglês

10.1126/science.182.4114.829

1095-9203

Phillip Görden, Maxine A. Lesniak, C. M. Hendricks, Jesse Roth,

Liver physiology and pathology

Plasma as well as pituitary immunoreactive human growth hormone (HGH) comprises at least two discrete components which have been designated as "big" HGH and "little" HGH. Using a newly developed radioreceptor assay, which depends on the ability of a substance to compete with labeled HGH for binding sites on cultured human lymphocytes, we find that the big HGH component from both normal and acromegalic subjects has much less activity in the radioreceptor assay than in the radioimmunoassay, whereas the little HGH component has similar activity in both assays.