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Effect of somatostatin on pancreatic protein secretion induced by cholecystokinin

1979; Elsevier BV; Volume: 26; Issue: 5 Linguagem: Inglês

10.1016/0022-4804(79)90038-6

1095-8673

Thomas A. Miller, Fern S. Tepperman, Wan-Fen Fang, Eugene D. Jacobson,

Pancreatic function and diabetes

Using an in vivo rabbit pancreas preparation, studies were conducted to determine the effect of somatostatin on pancreatic protein secretion induced by the octapeptide of cholecystokinin (OP-CCK) when directly infused intraarterially into the pancreatic parenchyma. Compared to control experiments in which no drugs were given, intraarterial infusion of OP-CCK (30 ng/ml) continuously for 1 hr at a rate of 0.33 ml/min significantly increased (P < 0.005) protein concentration and total protein output in the pancreatic juice without a corresponding change in volume. When given in combination with somatostatin (5 μg/ml) OP-CCK-induced pancreatic protein secretion was markedly inhibited (P < 0.05) without any effect on pancreatic volume output. The observation that volume flow remained unchanged during OP-CCK infusion alone and in combination with somatostatin suggests that the inhibitory effect of somatostatin is mediated through direct inhibition of protein synthesis or release at the level of the pancreatic acinar cell.