Editorial Revisado por pares

Cells brainwashed by FOXM1: do they have potential as biomarkers of cancer?

2012; Future Medicine; Volume: 6; Issue: 4 Linguagem: Inglês

10.2217/bmm.12.33

ISSN

1752-0371

Autores

Muy‐Teck Teh,

Tópico(s)

Chromatin Remodeling and Cancer

Resumo

Biomarkers in MedicineVol. 6, No. 4 General content - EditorialCells brainwashed by FOXM1: do they have potential as biomarkers of cancer?Muy-Teck TehMuy-Teck TehCentre for Clinical & Diagnostic Oral Sciences, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, The Blizard Building, 4 Newark Street, London E1 2AT, UK. Published Online:23 Aug 2012https://doi.org/10.2217/bmm.12.33AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: epigenetic biomarkersFOXM1precancer diagnosisprognostic biomarkerReferences1 Teh MT, Wong ST, Neill GW, Ghali LR, Philpott MP, Quinn AG. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res.62(16),4773–4780 (2002).Medline, CAS, Google Scholar2 Teh MT. Initiation of human tumourigenesis: upregulation of FOXM1 transcription factor. In: Stem Cells and Cancer Stem Cells (Volume 3). Hayat MA (Ed.). Springer, The Netherlands, 149–154 (2012).Google Scholar3 Myatt SS, Lam EW. The emerging roles of forkhead box (FOX) proteins in cancer. Nat. Rev. Cancer7(11),847–859 (2007).Crossref, Medline, CAS, Google Scholar4 Laoukili J, Kooistra MR, Bras A et al. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat. Cell Biol.7(2),126–136 (2005).Crossref, Medline, CAS, Google Scholar5 Gemenetzidis E, Bose A, Riaz AM et al. FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS ONE4(3),e4849 (2009).Crossref, Google Scholar6 Teh MT, Gemenetzidis E, Patel D et al. FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. PLoS ONE7(3),e34329 (2012).Crossref, CAS, Google Scholar7 Baylin SB, Jones PA. A decade of exploring the cancer epigenome – biological and translational implications. Nat. Rev. Cancer11(10),726–734 (2011).Crossref, Medline, CAS, Google Scholar8 Tsai HC, Baylin SB. Cancer epigenetics: linking basic biology to clinical medicine. Cell Res.21(3),502–517 (2011).Crossref, Medline, CAS, Google Scholar9 Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer11(6),426–437 (2011).Crossref, Medline, CAS, Google Scholar10 Waseem A, Ali M, Odell EW, Fortune F, Teh MT. Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol.46(7),536–542 (2010).Crossref, CAS, Google Scholar11 Gemenetzidis E, Costea DE, Parkinson EK, Waseem A, Wan H, Teh MT. Induction of human epithelial stem/progenitor expansion by FOXM1. Cancer Res.70(22),9515–9526 (2010).Crossref, CAS, Google Scholar12 Koo CY, Muir KW, Lam EW. FOXM1: from cancer initiation to progression and treatment. Biochim. Biophys. Acta1819(1),28–37 (2012).Crossref, Medline, CAS, Google Scholar13 Baron RC, Melillo S, Rimer BK et al. Intervention to increase recommendation and delivery of screening for breast, cervical, and colorectal cancers by healthcare providers a systematic review of provider reminders. Am. J. Prev. Med.38(1),110–117 (2010).Crossref, Google Scholar14 Haddad RI, Shin DM. Recent advances in head and neck cancer. N. Engl. J. Med.359(11),1143–1154 (2008).Crossref, Medline, CAS, Google Scholar15 Teh MT, Gemenetzidis E, Chaplin T, Young BD, Philpott MP. Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes. Mol. Cancer9(1),45 (2010).Crossref, Google Scholar16 Schwarzenbach H, Muller V, Milde-Langosch K, Steinbach B, Pantel K. Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease. Mol. Biosyst.7(10),2848–2854 (2011).Crossref, CAS, Google Scholar17 Kim C, Paik S. Gene-expression-based prognostic assays for breast cancer. Nat. Rev.7(6),340–347 (2010).CAS, Google Scholar18 Cuzick J, Swanson GP, Fisher G et al. Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study. Lancet Oncol.12(3),245–255 (2011).Crossref, Medline, CAS, Google Scholar19 Chibon F, Lagarde P, Salas S et al. Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nat. Med.16(7),781–787 (2010).Crossref, Medline, CAS, Google Scholar20 Kratz JR, He J, Van Den Eeden SK et al. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet379(9818),823–832 (2012).Crossref, Medline, Google ScholarFiguresReferencesRelatedDetailsCited ByMolecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implicationsOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 125, No. 6Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition12 November 2014 | Nature Communications, Vol. 5, No. 1FOXM1 (Forkhead box M1) in Tumorigenesis Vol. 6, No. 4 Follow us on social media for the latest updates Metrics Downloaded 239 times History Published online 23 August 2012 Published in print August 2012 Information© Future Medicine LtdKeywordsepigenetic biomarkersFOXM1precancer diagnosisprognostic biomarkerFinancial & competing interests disclosureThe author is listed as an inventor on a patent application at the World Intellectual Property Organisation filed by Queen Mary University of London pertaining to the use of a panel of biomarkers for cancer diagnosis. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

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