Synthesis and biodistribution of [18F]-5-fluorocytosine
1985; Lippincott Williams & Wilkins; Volume: 6; Issue: 8 Linguagem: Inglês
10.1097/00006231-198508000-00005
ISSN1473-5628
AutoresGerard W.M. Visser, Saskia Boele, Gertrudis H. J. N. Knops, Jacobus D. M. Herscheid, A. Hoekstra,
Tópico(s)Glioma Diagnosis and Treatment
Resumo[18F]-5-fluorocytosine was prepared by reaction of [18F]-acetylhypofluorite with cytosine in acetic acid and was isolated in an overall radiochemical yield of 20%. Tissue distribution studies in sarcoma-bearing rats indicated in vivo stability, limited tissue uptake and rapid urinary excretion.
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