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Effect of Isoproterenol Administration on Rat Heart Glutathione Status

1986; Taylor & Francis; Volume: 2; Issue: 1-2 Linguagem: Inglês

10.3109/10715768609088060

8755-0199

Carlo Guarnieri, Isabella Vaona, M Scheda, Claudio Marcello Caldarera,

Coenzyme Q10 studies and effects

The intraperitoneal administration of 3, 10 and 80 mg/Kg isoproterenol produced in the cardiac muscle a dose dependent increase of GSH content and a slight elevation of GSSG content. In addition, the treatment with the catecholamine at the doses of 3 and 10 mg/Kg produced a slight decrease of the mixed glutathione disulfides level, whilst at the dose of 80 mg/Kg, this effect was more pronounced. These changes were not accompanied by modifications of the activities of the enzymes glutathione peroxidase, glutathione reductase and glutathione S-transferase.