Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers
1992; Elsevier BV; Volume: 25; Issue: 1 Linguagem: Inglês
10.1016/0167-8140(92)90193-x
ISSN1879-0887
AutoresM.R.L. Stratford, Ana M. Rojas, Dianna W. Hall, M.F. Dennis, Stanley Dische, Michael C. Joiner, R.J. Hodgkiss,
Tópico(s)Metabolism and Genetic Disorders
ResumoThe pharmacokinetics of nicotinamide were studied in four human volunteers after oral doses of 1–6 g. Plasma concentrations and clearance rates of the vitamin were found to be dose-dependent, with a half-life of ∼7–9 h for the two highest doses administered (4 and 6 g), ∼4 h with 2 g and ∼1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1 μmol·ml−1 after a 6-g dose. The time to reach peak plasma concentration was dose independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no detectable effect on blood pressure, pulse or body temperature.
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