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The cytogenetic effect of rubidomycin in vivo in rats

1971; Elsevier BV; Volume: 12; Issue: 1 Linguagem: Inglês

10.1016/0027-5107(71)90076-5

1873-135X

Mogens Krogh Jensen, Preben Philip,

Carcinogens and Genotoxicity Assessment

The cytogenetic effect of rubidomycin in vivo was studied in bone marrow cells of Wistar rats. 24 h after the administration of rubidomycin in doses of 5 and 10 mg per kg body weight, from 60 to 85% of the metaphases showed structural chromosome abberations. The proportion of abnornal metaphases varied with the period that had elapsed since the administration of rubidomycin. Lymphocyte cultures from the peripheral blood of treated rats showed only a few percent of abnormal metaphases. It is concluded that when the cytogenetic effects of chemical agents are estimated, two factors should be taken into consideration, namely the period that has elapsed since the exposure to the drug, and the types of cell examined.