Enantioselective synthesis of α-hydroxyphosphonates through asymmetric Pudovik reactions with chiral lanthanoid and titanium alkoxides
1997; Issue: 10 Linguagem: Inglês
10.1039/a608161d
ISSN2050-8255
AutoresTsutomu Yokomatsu, Takehiro Yamagishi, Shiroshi Shibuya,
Tópico(s)Chemical Synthesis and Analysis
ResumoThe Pudovik reaction of aromatic aldehydes with diethyl phosphite catalysed by either tartrate-modified titanium(IV) alkoxides or binaphthol-modified lanthanoid alkoxides has been examined. The enantioselectivity for the Pudovik reaction catalysed by tartrate-modified titanium(IV) alkoxide 1 was strongly dependent upon the solvent used. The electronic nature of the carbonyl affected the enantioselectivity for the Pudovik reaction with the La-Li-BINOL complex 2.
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