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Immunohistochemical Profile of Human Pancreatic Pacinian Corpuscles

2010; Lippincott Williams & Wilkins; Volume: 39; Issue: 3 Linguagem: Inglês

10.1097/mpa.0b013e3181bc0372

1536-4828

Olivia García‐Suárez, M.G. Calavia, Francisco J. Pérez-Moltó, Covadonga Álvarez‐Abad, Pablo Pérez‐Piñera, Juan Manuel Dieste Cobo, José A. Vega,

Lipid Membrane Structure and Behavior

To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins.Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile.Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.