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Transient presence and functional interaction of endogenous GABA and GABA A receptors in developing rat optic nerve

1992; Royal Society; Volume: 247; Issue: 1319 Linguagem: Inglês

10.1098/rspb.1992.0022

1471-2954

Kaoru Sakatani, Joel A. Black, Jeffery D. Kocsis,

Nicotinic Acetylcholine Receptors Study

Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Sakatani Kaoru , Black Joel and Kocsis J. D. 1992Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerveProc. R. Soc. Lond. B.247155–161http://doi.org/10.1098/rspb.1992.0022SectionRestricted accessArticleTransient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve Kaoru Sakatani Google Scholar Find this author on PubMed Search for more papers by this author , Joel Black Google Scholar Find this author on PubMed Search for more papers by this author and J. D. Kocsis Google Scholar Find this author on PubMed Search for more papers by this author Kaoru Sakatani Google Scholar Find this author on PubMed , Joel Black Google Scholar Find this author on PubMed and J. D. Kocsis Google Scholar Find this author on PubMed Published:22 February 1992https://doi.org/10.1098/rspb.1992.0022AbstractGABA (γ-aminobutyric acid) is a major inhibitory synaptic neurotransmitter with widespread distribution in the central nervous system (CNS). GABA can also modulate axonal excitability by activation of GABAA receptors in CNS white matter regions where synapses and neuronal cell bodies are not present. Studies on cultured glia cells have revealed the synthesis of GABA in rat optic nerve O-2A progenitor cells that give rise to oligodendrocytes and type 2 astrocytes in vitro. We report here that: (i) GABA is detected by immuno-electron microscopy in intact rat optic nerve and is localized to glia and pre-myelinated axons during the first few weeks of postnatal development, but is markedly reduced or absent in the adult; and (ii) neonatal optic nerve is depolarized by GABAA receptor agonists or by the inhibition of GABA uptake. These results demonstrate the presence of functional GABAA receptors, and GABA uptake and release mechanisms in developing rat optic nerve, and suggest that excitability of developing axons can be modulated by endogenous neurotransmitter at non-synaptic sites.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. Previous Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Butt A, Fern R and Matute C (2014) Neurotransmitter signaling in white matter, Glia, 10.1002/glia.22674, 62:11, (1762-1779), Online publication date: 1-Nov-2014. 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This Issue22 February 1992Volume 247Issue 1319 Article InformationDOI:https://doi.org/10.1098/rspb.1992.0022PubMed:1349183Published by:Royal SocietyPrint ISSN:0962-8452Online ISSN:1471-2954History: Manuscript received14/10/1991Manuscript accepted09/12/1991Published online01/01/1997Published in print22/02/1992 License:Scanned images copyright © 2017, Royal Society Citations and impact Large datasets are available through Proceedings B's partnership with Dryad