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Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)

2005; Taylor & Francis; Volume: 19; Issue: 4 Linguagem: Inglês

10.1080/14786410412331271979

1478-6427

Helder Lopes Teles, Jefferson P. Hemerly, Patrícia M. Pauletti, J. R. C. Pandolfi, Ângela R. Araújo, Sandro Roberto Valentini, Maria Cláudia Marx Young, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva,

Biological Activity of Diterpenoids and Biflavonoids

An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-)syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24h. Activities could be observed for egonol against C6 (IC50 = 3.2 microg/mL) and Hep-2 (IC50 = 3.6 microg/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 microg/mL) and HeLa (IC50 = 5.3 microg/mL) cells.