Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction
2002; Elsevier BV; Volume: 58; Issue: 28 Linguagem: Inglês
10.1016/s0040-4020(02)00531-8
ISSN1464-5416
AutoresZsuzsanna Riedl, Bert U. W. Maes, Katrien Monsieurs, Guy L. F. Lemière, Péter Mátyus, György Hajós,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoSuzuki cross-coupling reaction of 2-alkyl(methyl and benzyl)-5-chloro-4-methoxy- and 2-alkyl(methyl and benzyl)-4-chloro-5-methoxypyridazin-3(2H)-ones with 2-formylphenylboronic acid afforded the corresponding biaryl products which were cyclized with ammonia to yield hitherto undescribed pyridazino[4,5-c]isoquinolinones. Removal of the N-benzyl protective group in position 2 yielded the unsubstituted tricyclic pyridazinones.
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