Portal de Periódicos da CAPES

Cytokine Dysregulation in Chronic Kidney Disease: How Can We Treat It?

2008; Karger Publishers; Volume: 26; Issue: 3 Linguagem: Inglês

10.1159/000126926

1421-9735

Juan Jesús Carrero, Mahmut İlker Yılmaz, Bengt Lindholm, Peter Stenvinkel,

Parathyroid Disorders and Treatments

As the kidney is the major site for elimination of many cytokines, the delicate equilibrium of pro-inflammatory cytokines and their inhibitors is clearly dysregulated in chronic kidney disease (CKD) patients. The consequences of the altered immune response in uremia lead to a state of persistent inflammation which is highly prevalent among CKD patients and is linked to complications such as the development of protein-energy wasting and atherosclerotic vascular disease. The present review aims at reviewing this complex orchestration of uremic cytokines beyond the well-studied interleukin-6 and tumor necrosis factor-α. Finally, we update our current understanding on anti-inflammatory treatment strategies in CKD patients, including nutritional and lifestyle measurements, pharmacological intervention and specific anticytokine strategies targeting the dialytic procedure.