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Phytoestrogens from Aspalathus linearis

2006; Pharmaceutical Society of Japan; Volume: 29; Issue: 6 Linguagem: Inglês

10.1248/bpb.29.1271

1347-5215

Naomi Shimamura, Toshio Miyase, Kaoru Umehara, Tsutomu Warashina, Satoshi Fujii,

Natural product bioactivities and synthesis

From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.