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Effects of polyoxyethylene cetyl ether on the absorption of 3',4'-dideoxykanamycin B from rat rectum

1983; Elsevier BV; Volume: 14; Issue: 2-3 Linguagem: Inglês

10.1016/0378-5173(83)90100-x

1873-3476

Tsuchiya Seishi, Yukihiko Aramaki, Shigenari Ozawa, Matsumaru Hideo,

Biopolymer Synthesis and Applications

The effects of the surface-active agent, polyoxyethylene cetyl ether (POEC), on the rectal absorption of 3' ,4'-dideoxykanamycin B (DKB) and on the rectal surface were examined in rats. With the in situ perfusion method, the absorption of this antibiotic was dependent on the drug concentration, but not on the surface-active agent com ntration. In the in vivo study, the suppository of emulsified base (o/w type) was favorable to increased absorption of the drug and its extent of bioavailability was about 50% as compared with intramuscular administration. To investigate the effect of POEC on the rectal surface, the release of protein, sugar, phospholipid and enzymes into the perfusate was determined. This experiment suggests that the enzymatic composition of rectal mucosal membrane is different from that of small intestine. Using scanning electron microscope, it was observed that the mucous on the rectal surface was only washed off by the perfusion of POEC. These results suggest that the epithelial cells are not seriously damaged by POEC and that POEC is a useful additive to promote the absorption of DKB from suppositories.