A uronic acid analogue of isofagomine lactam as a nanomolar glucuronidase inhibitor
2012; Elsevier BV; Volume: 53; Issue: 16 Linguagem: Inglês
10.1016/j.tetlet.2012.02.009
ISSN1873-3581
AutoresEmil Lindbäck, You Zhou, Óscar López, José G. Fernández‐Bolaños, Christian Pedersen, Mikael Bols,
Tópico(s)Lysosomal Storage Disorders Research
ResumoThe synthesis of (3S,4R,5R)-3,4-dihydroxypiperidin-2-one-5-carboxylic acid ('isofagomine lactam uronate') from d-arabinose is reported. The product is a potent inhibitor in the low nanomolar range (Ki 36 nM) for bovine liver β-glucuronidase.
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