Produção Nacional
Hodgkin Lymphoma Among Patients Infected with HIV in Post-HAART Era
2007; Elsevier BV; Volume: 7; Issue: 5 Linguagem: Inglês
10.3816/clm.2007.n.014
ISSN1938-0712
AutoresPaula Yurie Tanaka, Vicente Porfírio Pessoa, Luís Fernando Pracchia, Valéria Buccheri, D.A.F. Chamone, Edenilson Eduardo Calore,
Tópico(s)Cytomegalovirus and herpesvirus research
ResumoHodgkin lymphoma is considered a common type of non-AIDS defining tumor among patients infected with HIV, commonly presenting as a widespread disease and with different pathologic features compared with Hodgkin lymphoma in the general population. Despite that, the best treatment option is undefined. The authors present a retrospective study of 31 patients with Hodgkin lymphoma–HIV attended at 3 Brazilian centers, 2 of them considered reference centers for HIV treatment. Chemotherapy schemes used were ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) or hybrid MOPP-ABV (mechlorethamine/vincristine/ procarbazine/prednisone-doxorubicin/bleomycin/vinblastine), with prophylactic granulocyte colony-stimulating factor. Treatment response could be evaluated in 22 patients (70.9%) who completed Initials treatment: 20 (91%) reached complete remission, 1 had partial remission, and 1 did not exhibit a response. The overall response rate was 95.5% (95% confidence interval, 91.2%-99.8%). After a median follow-up of 3 years, the overall survival (OS) rate among all patients was 80.3%; median OS was not reached. On univariate analysis, only CD4 cell count at diagnosis was significantly related to survival. This retrospective study shows that for patients with Hodgkin lymphoma development in the HIV setting in these 3 Brazilian centers, there was high complete remission and satisfactory OS rates, comparable with results found for Hodgkin lymphoma in patients without HIV.
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