The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus
2005; American Society for Microbiology; Volume: 187; Issue: 20 Linguagem: Inglês
10.1128/jb.187.20.7161-7164.2005
ISSN1098-5530
AutoresSarah O’Flaherty, Aidan Coffey, William J. Meaney, Gerald F. Fitzgerald, R. Paul Ross,
Tópico(s)Genomics and Phylogenetic Studies
ResumoThis study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis. Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus. LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.
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