Failure of Recommended Treatment for Secondary Syphilis
1986; American Medical Association; Volume: 255; Issue: 13 Linguagem: Inglês
10.1001/jama.1986.03370130123036
ISSN1538-3598
Autores Tópico(s)Reproductive tract infections research
ResumoTHE CENTERS for Disease Control (CDC) currently recommends that early syphilis (primary, secondary, and latent syphilis of less than a year's duration) be treated with 2.4 million units of penicillin G benzathine administered intramuscularly (IM) at a single session. 1 This treatment schedule has been found to have a clinical and/or serological failure rate ranging from less than 1% to 3%. 2-4 Other regimens have been reported to be more effective, 5,6 and controversy exists regarding optimal antibiotic treatment of early disease. We recently witnessed a dramatic relapse of secondary syphilis that occurred five months after the patient had been treated according to current CDC guidelines. Report of a Case A 21-year-old white male homosexual was admitted to Strong Memorial Hospital of the University of Rochester, NY, in July 1984, with a generalized rash, left leg weakness, and a positive rapid plasma reagin test (RPR). He had been sexually active
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