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Some desmoid tumors are characterized by trisomy 8

1994; Wiley; Volume: 10; Issue: 2 Linguagem: Inglês

10.1002/gcc.2870100208

1098-2264

Paola Dal Cin, Raf Sciot, Magdy Sayed Aly, Jan Delabie, Margareta Stas, Ivo De Wever, Boudewijn Van Damme, Herman Van den Berghe,

Tumors and Oncological Cases

Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on short-term cultures and frozen sections. Trisomy 8 was detected in four out of ten tumors, of which only one had shown trisomy 8 by karyotype analysis. Since trisomy 8 has been reported in superficial fibromatoses, which are clinically distinct but histologically similar to desmoid tumors, the occurrence of trisomy 8 in both may be a further indication of a close relationship.