Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins
2010; Elsevier BV; Volume: 81; Issue: 7 Linguagem: Inglês
10.1016/j.fitote.2010.04.009
ISSN1873-6971
AutoresAurelia Tubaro, Anna Giangaspero, Silvio Sosa, Roberto Negri, Gianpaolo Grassi, S. Casano, R. Della Loggia, Giovanni Appendino,
Tópico(s)Ion Channels and Receptors
ResumoA selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.
Referência(s)