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Positron Emission Tomography Shows Reduced Striatal Dopamine D1 but not D2 Receptors in Juvenile Neuronal Ceroid Lipofuscinosis

2002; Thieme Medical Publishers (Germany); Volume: 33; Issue: 3 Linguagem: Inglês

10.1055/s-2002-33677

1439-1899

J. O. Rinne, Hanna Ruottinen, K. NÃ¥gren, Leonard H. van den Berg, Pirkko Santavuori,

Retinal Development and Disorders

We studied striatal dopamine D1 and D2 receptors in patients with juvenile neuronal ceroid lipofuscinosis (JNCL) with positron emission tomography (PET) using a dopamine D1 receptor antagonist [11C]NNC 756 and a dopamine D2 receptor antagonist [11C]raclopride as ligands.