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Prevention of peritoneal adhesion using a bacterial cellulose hydrogel, in experimental study

2015; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 30; Issue: 3 Linguagem: Inglês

10.1590/s0102-865020150030000005

1678-2674

Elísio Rodrigues Coelho, Laura Olinda Bregieiro Fernandes Costa, Arinaldo Vasconcelos de Alencar, Ana Paula Guimarães Barbosa, Flávia Crisina Morone Pinto, José Lamartine de Andrade Aguiar,

Intestinal Malrotation and Obstruction Disorders

PURPOSE: To analyze the effectiveness of bacterial cellulose hydrogel as a barrier in preventing postoperative peritoneal adhesion in rat model. METHODS: Experimental study with 45 Wistar rats (Rattus norvegicus) that were divided into three groups for the following treatments: A. Saline, B. Oxidized Regenerated Cellulose (ORC) barrier, and C Bacterial Cellulose Hydrogel (BCH) barrier. After 45 days of the surgery the adhesions were classified and graded according to the qualitative score. The histological parameters were evaluated using a modified semi-quantitative scale to rate the extent of fibrosis, inflammatory reaction and vascular proliferation. RESULTS: Compared with the saline group (A), the treatments with ORC barrier (B) and BHC barrier (C) resulted in a smaller number of adhesions (p=0.019 and p=0.003 on Fisher's exact test, respectively). Data from inflammation and neovascularization showed no statistically significant difference between the groups BHC and ORC (p=0.426 and 0.446 on chi-square test, respectively). CONCLUSION: Bacterial cellulose hydrogel is effective as a bio-re-absorbable barrier for preventing postoperative peritoneal adhesions.