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Time Course of PAF Formation by Gastrointestinal Tissue in Rats After Castor Oil Challenge

1992; Oxford University Press; Volume: 44; Issue: 3 Linguagem: Inglês

10.1111/j.2042-7158.1992.tb03586.x

2042-7158

A Pintoy, Giuseppina Autore, Nicola Mascolo, Raffaella Sorrentino, Andrea Biondi, Angelo A. Izzo, Francesco Capasso,

Lipid metabolism and biosynthesis

Abstract When castor oil was administered by gavage to rats, the duodenum and jejunum, but not the stomach, produced large amounts of platelet activating factor 3–7 h after oil challenge with a peak at 3 h. Intraluminal release of acid phosphatase was also markedly increased in the duodenum and jejunum of castor oil-treated rats, especially 3–5 h after oil challenge. No increase was observed in the stomach. There was a correlation between elevated release of acid phosphatase and intestinal hyperaemia.