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The role of pharmacologic manipulation in adrenal cortical scintigraphy

1981; Elsevier BV; Volume: 11; Issue: 2 Linguagem: Inglês

10.1016/s0001-2998(81)80042-6

1558-4623

Milton D. Gross, Timothy W. Valk, Dennis P. Swanson, James H. Thrall, William H. Beierwaltes,

Adrenal and Paraganglionic Tumors

Adrenal scintigraphy is a unique nuclear medicine procedure that provides noninvasive, functional information concerning the status of the adrenal cortex. The uptake of iodocholesterol, in addition to localizing adrenal cortical abnormalities, can be manipulated to focus on adrenal cortical dysfunction in either the aldosterone, corticol, or androgen-producing portions of the adrenal cortex. The uptake of iodocholesterol correlates significantly with the abnormal secretion of cortisol in Cushing's syndrome, aldosterone in a model of adrenal zona glomerulosa function, and adrenal androgen secretion in hyperandrogenism. For these reasons, adrenal scintigraphy is an important diagnostic modality in the evaluation of adrenal cortical function.