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Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation

2013; National Academy of Sciences; Volume: 110; Issue: 50 Linguagem: Inglês

10.1073/pnas.1313654110

1091-6490

Joanne L. Jones, Sara Thompson, Priscilla Loh, Jessica L. Davies, Orla Tuohy, Allison J. Curry, Laura Azzopardi, Grant Hill-Cawthorne, Michael Fahey, Alastair Compston, Alasdair Coles,

Systemic Lupus Erythematosus Research

Significance This paper identifies the mechanism by which patients with multiple sclerosis develop secondary autoimmunity after treatment with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath-1H). In identifying this mechanism, it shows that T-cell homeostatic proliferation can lead to autoimmunity in humans. Alemtuzumab is one of the most effective treatments of multiple sclerosis tested to date; it is currently licensed in the European Union and under consideration by the Food and Drug Administration. Understanding what drives its most significant side effect is of clear clinical importance.