Interconversion of (R) and (S)-α-hydroxy esters: precursors of (S) and (R)-o-benzyl-α-hydroxylamino acid esters of high optical purity
1988; Elsevier BV; Volume: 44; Issue: 17 Linguagem: Inglês
10.1016/s0040-4020(01)86063-4
ISSN1464-5416
AutoresR. Feenstra, E. H. M. STOKKINGREEF, R. J. F. Nivard, H. C. J. OTTENHEIJM,
Tópico(s)Chemical Synthesis and Analysis
Resumo(R)- and (S)-α-hydroxy esters 5 are interconverted via their triflates 6 in high chemical as well as optical yields by reaction with dimethylformamide. The same triflates are efficiently converted into N-hydroxy-α-amino acid derivatives 7 of high optical purity.
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